It is possible that you may experience some or none of these HPV vaccine side effects explained above. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have side effects from a medicine that you have never tried. Therefore, make sure to let your healthcare provider know if you develop any side effects. Also, let your healthcare provider know if you develop something that "just does not seem right." While it may not be an HPV vaccine side effect, your healthcare provider will be able to diagnose and treat the problem.