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Drug Interactions With the HPV Vaccine

As with most medications, there are potential drug interactions with the HPV vaccine. Taking the HPV vaccine with other medications, such as anticoagulants, immunosuppressants, or other vaccines, can cause potential bleeding under the skin and in the muscles, or may cause the HPV vaccine to not work as well as it should. Interactions with the HPV vaccine and other vaccines have not been thoroughly studied, so the effects are not completely known. It is important to talk to your doctor about any HPV vaccine drug interactions that may apply to you.

 

An Overview of HPV Vaccine Drug Interactions

Quadrivalent Human Papillomavirus (Types 6, 11, 16, and 18) Recombinant Vaccine (Gardasil®) can potentially interact with many drugs. Some of the drugs that may lead to HPV vaccine interactions include:
 
  • Anticoagulants, including:
o Dalteparin (Fragmin®)
o Enoxaparin (Lovenox®)
o Heparin
o Warfarin (Coumadin®, Jantoven®)
  • Immunosuppressants, such as:
o Certain monoclonal antibodies, including:
o Corticosteroids, such as:
      • Betamethasone (Celestone®)
      • Corticotropin
      • Cortisone
      • Dexamethasone (Decadron®)
      • Fludrocortisone (Florinef®)
      • Hydrocortisone (Cortef®)
      • Methylprednisolone (Depo-Medrol®, Medrol®)
      • Prednisolone (Pediapred®)
      • Prednisone
      • Triamcinolone (Kenalog®)
o Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
o Lenalidomide (Revlimid®)
o Methotrexate (Rheumatrex®)
o Mycophenolate (CellCept®)
o Nelarabine (Arranon®)
o Sirolimus (Rapamune®)
o Tacrolimus (Prograf®)
o Thalidomide (Thalomid®)
o Trimetrexate (NeuTrexin®)
  • Other vaccines.
     
(Drug Interactions With the HPV Vaccine Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;