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Drug Interactions With the HPV Vaccine

As with most medications, there are potential drug interactions with the HPV vaccine. Taking the HPV vaccine with other medications, such as anticoagulants or immunosuppressants, can cause potential bleeding under the skin and in the muscles, or may cause the HPV vaccine to not work as well as it should. Interactions with the HPV vaccine and other vaccines have not been thoroughly studied, so the effects are not completely known.

An Overview of HPV Vaccine Interactions

The HPV vaccine (Gardasil®, Cervarix®) can potentially interact with many drugs. Some of the drugs that may lead to HPV vaccine interactions include:
      • Alteplase (Activase®)
      • Reteplase (Retavase®)
      • Streptokinase (Streptase®)
      • Tenecteplase (TNKase®)
  • Immunosuppressants, such as:


    • Corticosteroids, such as:


      • Betamethasone (Celestone®)
      • Corticotropin
      • Cortisone
      • Dexamethasone (Decadron®)
      • Fludrocortisone (Florinef®)
      • Hydrocortisone (Cortef®)
      • Methylprednisolone (Depo-Medrol®, Medrol®)
      • Prednisolone (Pediapred®)
      • Prednisone
      • Triamcinolone (Kenalog®)



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